Maternal imprinting defect
نویسندگان
چکیده
منابع مشابه
Maternal "imprinting" in Goats.
Some years ago Collias1 reported a study on maternal-filial bonds in goats in which he suggested that events transpiring during a brief post partum period were particularly important. As part of our studies of the ontogenesis of social behavior, we have sought to subject the putative importance of this period to a further analysis, with special attention to its precise boundaries (if any) and t...
متن کاملGenomic imprinting, maternal care, and brain evolution.
The majority of autosomal genes are inherited as two copies, one from each parent, and such biallelically inherited genes have identical functions. Genomic imprinting confers different functions on the two parental genomes during development by silencing one allele of each imprinted gene in a parent-oforigin-dependent manner. Hence imprinted genes usually function when inherited either from the...
متن کاملInbreeding, maternal care and genomic imprinting.
Inactivation of expression of the paternal allele at two maternally silent imprinted loci has recently been reported to diminish the quality of care that female mice lavish on their offspring. This suggests that there can be disagreement between the maternally and paternally derived genomes of mothers over how much care for offspring is appropriate, with the paternally derived genome favoring g...
متن کاملA GNAS1 imprinting defect in pseudohypoparathyroidism type IB.
Pseudohypoparathyroidism type IB (PHPIB) is characterized by renal resistance to parathyroid hormone (PTH) and the absence of other endocrine or physical abnormalities. Familial PHPIB has been mapped to 20q13, near GNAS1, which encodes G(s)alpha, the G protein alpha-subunit required for receptor-stimulated cAMP generation. However, G(s)alpha function is normal in blood cells from PHPIB patients...
متن کاملAn Unexpected Function of the Prader-Willi Syndrome Imprinting Center in Maternal Imprinting in Mice
Genomic imprinting is a phenomenon that some genes are expressed differentially according to the parent of origin. Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are neurobehavioral disorders caused by deficiency of imprinted gene expression from paternal and maternal chromosome 15q11-q13, respectively. Imprinted genes at the PWS/AS domain are regulated through a bipartite imprinting ce...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2011
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.967